Genetic Analysis Suggests Squirrels Contributed to the Global Spread of Leprosy

Genetic Analysis Suggests Squirrels Contributed to the Global Spread of Leprosy

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Leprosy is one of the oldest known diseases to afflict humans, yet its origin is mired in controversy. A new study, in which 10 strains of the disease were detected in the remains medieval Europeans, is now complicating the picture even further by pointing to western Europe as a potential launching point for leprosy. What’s more, the evidence also points to squirrels as a major contributing factor in the spread of the dreaded disease.

Archaeological, historical, and paleontological accounts of a sickness consistent with leprosy date back thousands of years to Africa and the Middle East. Caused by the bacterium Mycobacterium leprae, leprosy became widespread in medieval Europe, peaking between the 12th and 14th century and finally declining by the 16th century. Leprosy, also known as Hansen’s disease, affects the nerves, skin, eyes, and lining of the nose, and it’s still endemic in many parts of the world, with 200,000 new cases reported each year.

The origin and dissemination of M. leprae remains a mystery, despite many attempts to reconstruct its past from historical and archaeological sources. A popular theory is that it originated in East Africa or the Levant area of the Middle East, moving around the globe as humans traveled along migration and trade routes. Other evidence points to its origin in East Asia.

But as new research published today in PLOS Pathogens points out, medieval Europe was an absolute hotbed for the disease in terms of its genetic diversity. This latest research doesn’t prove that leprosy originated in Europe or anywhere else for that matter, nor are its authors making this claim, but the presence of 10 different strains of leprosy in western Europe during the Middle Ages, including the oldest genetic strain found in the UK, certainly hints at this possibility.

And then there are Britain’s red squirrels to consider—but more on this tantalizing clue in just a bit.

Skeletal remains showing evidence of leprosy from the Odense St. Jørgen cemetery in Denmark, which was established in 1270 and existed until 1560.
Image: Dorthe Dangvard Pedersen

For the new study, researchers from the Max Planck Institute for the Science of Human History at the University of Tübingen, EPFL Lausanne, the University of Zurich, and several other institutions analyzed the remains of 90 individuals buried across Europe and dating to between 400 AD to 1400 AD. All of these individuals exhibited skeletal deformations consistent with leprosy, including deformations in the face (particularly around the nose), as as well as in the toe and finger bones. These leprosy cases came from various parts or Europe, including Italy, Hungary, the Czech Republic, and the UK.

“Our samples come from museum collections and their pathologies were already examined by paleopathologists and published previously,” Verena J. Schuenemann, an archaeologist from the University of Tübingen and the lead author of the new study, explained to Gizmodo. “In our study, we use well-established methods for ancient DNA, which have also been used in previous publications on ancient leprosy genomes.”

Working with these remains, the researchers extracted, identified, and reconstructed 10 medieval M. leprae genomes, several of which were previously known to science. The researchers also found multiple instances of leprosy strains in the same cemetery, showcasing the diversity of the disease as it made its way across the continent during this time period.

“We found that almost all major lineages of Mycobacterium leprae are present in medieval Europe,” said Schuenemann. “This finding leads to new models about the past spread and diversity of leprosy. It suggests that leprosy may already have been widespread throughout Asia and Europe in antiquity or that it might have originated in western Eurasia.”

A big surprise was the high diversity of the ancient M. leprae strains recovered from the samples. “In particular, we did not expect such a diversity within the same cemetery, as we found three major lineages within the St. Jorgen cemetery in Denmark,” she said. Prior to this study, scientists thought the disease only existed as several strains, only two of which were present in Medieval Europe. This latest research is now challenging that assumption.

Skeletal remains from Great Chesterford showing evidence of leprosy. This is the oldest known case of leprosy in the UK.
Image: Sarah Inskip

One of the sequenced genomes came from the remains of an individual who lived in Great Chesterford England between 415 to 545 AD, making it the oldest M. leprae genome found in the UK. Intriguingly, this strain is very similar to those found in modern-day red squirrels, who are carriers of a medieval strain that stopped afflicting Europeans over 700 years ago.

“This supports the hypothesis that squirrels and the squirrel fur trade were a factor in the spread of leprosy among humans in Europe during the medieval period,” said Schuenemann.

Previous research shows that Vikings, via the squirrel fur trade, may have introduced the disease to Denmark and Sweden, possibly as early as 888 to 1015 AD. Or maybe the Vikings or other squirrel fur traders spread leprosy to Britain—we don’t know. Squirrels were also a common pet in those times, as the paper describes:

Moreover, squirrels were hunted for food, and often used as pets. For example, squirrels are commonly depicted wearing collars and leashes in medieval art and they were mentioned in historical letters as pets in monasteries. The keeping of squirrels in the domestic space could be envisioned as a possible mechanism for a transfer of M. leprae between species.

But scientists still aren’t sure if humans infected squirrels with leprosy, or if it was the other way around. Further complicating the matter is genetic evidence from 2014 suggesting early modern humans were already carrying leprosy when migrating out of Africa around 100,000 years ago.

The new study doesn’t resolve any of these issues, unfortunately. Why was leprosy so diverse in Europe during the Middle Ages? And how did it get to the UK so long ago?

Unfortunately, no ancient genomes from key regions in Asia or elsewhere are currently available, preventing further testing of current hypotheses. Schuenemann says it’s crucial that scientists locate more ancient and ancestral strains to push this research further. Until that happens, however, the story of leprosy, and how it came to afflict our species, remains an unresolved mystery.

[PLOS Pathogens]

Tech

via Gizmodo http://gizmodo.com

May 10, 2018 at 02:03PM

Hurricane Harvey was fueled by record heat in the Gulf of Mexico

Hurricane Harvey was fueled by record heat in the Gulf of Mexico

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Enlarge /

Warm sea surface temperatures on August 23, 2017, just before Hurricane Harvey.

We’ve covered several studies seeking to clarify the role of human-caused climate change in the unbelievable amounts of water Hurricane Harvey dumped on Houston last year. The general approach of these studies was to simulate today’s climate and a pre-global-warming climate, and to then compare the behavior of hurricanes around Houston.

Since most people understand that hurricanes are fueled by warm ocean water, however, perhaps it would be conceptually simpler to focus on the seawater beneath Harvey.

Tech

via Ars Technica https://arstechnica.com

May 10, 2018 at 12:43PM

Are Air Fryers Worth It?

Are Air Fryers Worth It?

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A few months back, I went to a kitchen appliance trade show and was surprised by the large number of manufacturers coming out with air fryers. “Enjoy great tasting fried food”[sic] reads the cover recipe booklet for Philip’s new Airfryer XXL, a lovely sounding idea. With their focus on faux fried flavor, an aversion to fat, and an emphasis on convenience in the marketing from almost every manufacturer, the rise of air fryers felt like the second coming of the George Foreman Grill.

Honestly, though, I was suspicious. Wasn’t air frying more of a tweaked version of baking than a luxurious, crisp-making wallow in hot oil?

I called in one of Philips new XXL models, which is both large and a good representative of the best of the industry’s offerings.

It arrived in the morning and, lacking other options in my fridge and pantry, I made baked potatoes for my wife Elisabeth and myself. Pulling the air fryer out of the box, three things became immediately apparent. First, these things take up a lot of counter space—pretty much the footprint of a five-gallon bucket, and two-thirds the height. (Other brands might be smaller but not that much.) Second, the fan that that runs whenever it’s on is loud, effectively sucking the conversation or ambient music right up into the ether. The third thing was how ridiculously tiny the cooking basket is; at nine inches by nine inches by two and three-quarter inches high, two large potatoes effectively maxed out its capacity.

The spuds were good but that was more of a sour cream, cheddar, and chives thing than an air fryer thing. Clearly, more testing was in order.

Heat Wave

What is it that makes air fryers unique? The answer might be, “Nothing, really.” Air fryers are convection ovens in a bucket, meaning that like a regular oven, they have a heating element and like a slightly fancier oven with a convection feature, they have a fan that circulates the hot air, keeping the temperature consistent throughout the cooking area. Thanks to faster-than-a-normal-oven heat transfer capabilities from that rapidly circulating air, convection ovens can shorten the cooking time of some foods, potentially giving them a crispier exterior that brand-conscious marketeers seem to consider to be similar to fried food.

An air fryer would be flattened in a mano-a-mano with a real Fryalator and its big tub of hot oil.

Let’s be clear, though: an air fryer would be flattened in a mano-a-mano with a real Fryalator and its big tub of hot oil. Few of us deep fry at home, though, as it involves that huge amount of hot oil which you have to deal with after dinner. So does air frying bring us close enough to the ideal to take the plunge?

I’d been back and forth with a Philips representative, asking for suggestions on what to cook that really put the machine’s skills to the fore, and was flummoxed when they suggested frozen french fries.

“Hell,” I thought. “I’ll bite.”

I went to the store and there they were, same brand and everything. I split up the bag, and started one batch in the air fryer, and another in my oven with the convection off, then made a follow-up batch using the convection setting. The air fryer fries were nicely browned and crisp, but a bit hollowed out, seemingly at the expense of some pleasant creaminess inside. The no-convection oven batch was more leathery on the outside, creamy within, and noticeably less browned. The convection oven version landed squarely between the two.

While all three specimens were reminiscent of special treats mom would make for my sister and I when we were kids and she didn’t want to cook, they were in no way as good as real French fries. If a perfect paper cone full of Belgian fries eaten on a Brussels sidewalk is a 10 and excellent fries at your favorite bar are a seven, then the oven fries were a two, the convection oven version was a two point five and the air fryer a three. With a bit of tweaking, like preheating the sheet pan for the oven version, I guessed I could bring each of those home-cooked numbers up a point, but none of the fries I’d made were terribly compelling.

For the Birds

Another recommended recipe was a whole chicken like the one found on the cover of the XXL’s recipe booklet. Having now used the machine, I had some serious geometry questions, most significantly how to cram a whole bird into the air fryer’s basket.

The booklet sneakily recommended cooking a three-pounder, but I sensed trouble. Birds that small aren’t easy to find at Safeway. Elisabeth checked at the grocery store near my house and after flipping through a bin of chickens, she couldn’t find one smaller than 3.5 pounds. Considering it’s an organic market and those birds tend to be smaller than the typical Oven Stuffer Roaster, this was disconcerting.

I called my butcher, who said theirs are almost always larger than three pounds, but that they’d root around for me.

“We found a runt!” she said, holding the tiny fowl aloft when I walked into the shop. It weighed 2.75 pounds. I bought that one along with a 3.25 pounder, planning to roast them both for friends.

I preheated the air fryer and my oven, prepped the birds and immediately ran into trouble. I had to cram the tiny chicken into the air fryer basket, and as soon as I closed the door, I could smell something burning. I’d clearly exceeded the height limit for this ride, and now dinner was running late. I fished the slightly singed chicken out, set it on a cutting board and—getting a little desperate since people were on the way over—did what must have looked like man-on-chicken chest compressions in an attempt to break the backbone, or at least flatten the thing out a bit before performing some innovative re-trussing. Surprisingly, it worked.

Taking a bite, the meat was surprisingly juicy, but the crust was horrible, with a peculiar texture that, while sloughing around between my teeth, reminded me of shale.

In my relatively tiny oven, I perched the larger bird on a bunch of vegetables: onion quarters, whole carrots, and fennel. Below that, I used the free space to roast another tray of veggies. When I pulled the oven chicken out, I put the veggies in the roasting pan up by the broiler for a quick bit of extra browning.

It all made for a lovely meal, particularly once I could turn off the air fryer and hear our guests. The air fryer chicken was tiny but tasty with crispy skin, perhaps even superior to the oven-roasted bird. That said, its advantage over the oven chicken might just be because it finished earlier, and I wanted to get food on the table.

From there, I tried another recipe in the Philips recipe booklet: shrimp on lemongrass skewers with sweet potato fries. The idea is that you’re supposed to cook it all in batches, a detail that subtly pops up on the very last line of the recipe. My estimate is that you’d have to do the fries in (at least) two batches, followed by the shrimp in two, turning it into 60 minutes of cooking time. Compare that to cooking the fries in the oven (there wasn’t much difference in taste in the fries between the three methods), then blasting the shrimp under the broiler. Don’t get me wrong, the results of all three methods for the shrimp were excellent, but the oven and broiler gave me more options and slightly superior results, and, thanks to the relatively luxurious amount of space in my oven, I could cook much more food in about half the time.

The air fryer hail Mary was buttermilk fried chicken. If I could pull it off, I thought, it’d be pretty fantastic. The recipe starts out right, marinating chicken thighs in buttermilk for hours before dredging them in flour, and dropping them into the air fryer.

Oh, friends! It was so sad! I could only cook four thighs at a time, despite the recipe’s idea that you could fit six. (Where do they find these miniature chickens? Why not call for a broiler or a squab?) Two people would need to wait an hour of “fry” time to get more than two pieces each—often a necessity with good fried chicken. When done, the exterior was blotchy and scaly, and vaguely, but not really, fried-looking. Taking a bite, the meat was surprisingly juicy, but the crust was horrible, with a peculiar texture that, while sloughing around between my teeth, reminded me of shale.

It also recalled a bender I went on while researching a story about chicken wings in Buffalo. There, at a bar called Kelly’s Korner, a very large man named T.C. railed against the heretical idea of ranch dressing being served alongside his flats and drumettes.

“If someone ever gives you ranch dressing,” he exclaimed before downing a shot of Jameson’s, “you throw that shit against the wall!”

Nothing flew against the wall in my test kitchen, but attempting fried chicken in an air fryer was miserably unworthy of reproduction.

Sorry, Please Fry Again

So here’s the deal: you don’t need one of these things. They’re loud, even the big ones have a surprisingly small capacity, they don’t do anything significantly better than an oven and you probably have an oven anyway. They’d also require bumping your toaster and coffeemaker onto a storage shelf.

Instead, if you’re into the air-frying idea, save the potentially significant amount of money you’d spend on one (high-end models can cost $400 or more) and upgrade to a convection feature the next time your real oven croaks.

The marketing materials for the scores of companies that make these hot-air blowers will tell you that they are a great way to cook that cuts down on fat. But good lord, fried is fried, and “air fried” is not that. Better to eat well most of the time then go to your favorite fried chicken place on your birthday, or do it up at home with a couple of liters of canola oil and a Dutch oven. The rare dose of perfection is far better than the consistent drip of mediocrity.

Food writer Joe Ray (@joe_diner) is a Lowell Thomas Travel Journalist of The Year, a restaurant critic, and author of “Sea and Smoke” with chef Blaine Wetzel.

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May 10, 2018 at 07:06AM

Equifax Operates Another Credit Bureau, and You Can’t Freeze Your Report Online

Equifax Operates Another Credit Bureau, and You Can’t Freeze Your Report Online

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Remember all that trouble you went through to freeze your credit report after the massive and unforgivable Equifax hack? Turns out it was all for nothing, as security writer Brian Krebs reported Wednesday that the same company responsible for compromising the security of nearly two-thirds of the adult population of the United States also operates a secondary credit bureau that is plagued with security vulnerabilities.

The shady-looking credit reporting institution is the National Consumer Telecommunications and Utilities Exchange (NCTUE), and it’s been operating outside the walls of the Big Three credit bureaus of Equifax, Experian, and TransUnion that we typically hear about.

The NCTUE was established in 1997 by AT&T as a way to maintain records on payment and account history reported by telecommunications companies, cable operators, and utility service providers. Members of the NCTUE include AT&T; the New York Data Exchange, which has a partnership with Verizon; the California Utility Exchange; and Centralized Credit Check Systems, which has next to no web presence whatsoever and is shrouded in mystery.

Equifax operates both the New York Data Exchange and the California Utility Exchange. According to Krebs, the company best known for the data breach apocalypse last year is the sole contractor in charge of managing the NCTUE database, and the whole thing is hosted on Equifax’s servers, which does not inspire a whole lot of confidence.

If you’ll recall, not only did Equifax manage to suffer from an all-timer of a hack, but it also followed it up with one of the worst-executed damage control campaigns imaginable. The site the company set up for consumers to check if they were affected by the breach asked for six digits of the visitor’s social security number, then told people their data was exposed no matter what they entered. The website itself was also vulnerable to hacking, not that it really mattered all that much seeing as Equifax sent people to a phishing site set up to look just like the real one.

This is the company in control of consumer information stored in a database that has thus far avoided the spotlight placed on credit reporting firms by last year’s breach. Krebs wrote that with a call to the NCTUE hotline and information like a person’s social security number and the numeric part of their home address—information pretty readily available online now, thanks to Equifax—it’s possible to order a credit report from the lesser-known bureau.

It is possible to freeze your credit score through NCTUE as well, but it’s not all that easy. Krebs describes the online process for placing a freeze on NCTUE reports as “completely borked at the moment.” Oh, and the site has an invalid SSL certificate, which means communications with the site are not encrypted and secure. So there’s that!

It is possible to place a freeze on your credit report through NCTUE by calling the 1-800 hotline at 1-866-349-5355, though be warned that you might incur a fee for the process.

[Krebs on Security]

Tech

via Gizmodo http://gizmodo.com

May 10, 2018 at 12:03AM

Chrome will let you have AR experiences, no app needed

Chrome will let you have AR experiences, no app needed

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Google believes that 2018 is the year the web turns a corner and starts becoming more immersive, and the company’s new WebXR API is at the heart of its efforts. Long story short, WebXR provides a platform to more easily optimize and integrate VR and AR experiences right into web browsers, and developers can start crafting VR experiences for Chrome with the API today. In-browser VR has been a thing for a while, though — web-based AR, however, feels more immediately helpful. It’ll be a while before you can virtually plop 3D objects into an augmented reality space inside Chrome, but we just got to take it for a spin and honestly, the AR-friendly web can’t arrive soon enough.

Let’s set the stage a little bit first. A Google staffer handed me a Pixel 2XL with a prerelease Chromium build, and the only demo available gave me the power-skim through a webpage and dropped an Aztec-offering vessel called a chacmool onto the floor in front of the phone. (Turns out, chacmool were typically used for ceremonial offerings and sacrifices, but this one was free of virtual blood.) Google’s demo was pretty basic as far as AR experiences go, but even at this early stage it worked much, much better than I expected. I’ve used full-blown standalone AR apps that didn’t feel as smooth as this: I could move the vessel around the room, rotate it with two fingers, and get nice and close for proper scrutiny with 6 degrees of freedom.

Simply poking around was neat enough, but there was a strong educational angle too. Floating data points hovering around the chacmool offered additional information and context when tapped. I wouldn’t have thought much of the statue’s red and blue feet, but a quick tap revealed that the red and blue paint used to color the chacmool’s sandals helped researchers connect it in time with other pieces of artwork found in Mexico. I always walk away from I/O with a few tidbits of random information tucked away in my head, but I certainly didn’t expect to leave with a better understanding of Meso-American art. The demo was actually highly reminiscent of time spent wandering around a museum in Barcelona with a Google Tango-powered tablet, except this time I didn’t need specialized hardware. For education and the perpetually curious, web AR is going to feel tremendously valuable.

While the impact of AR in a web browser is already very clear, one weighty question remains: when can people actually use this stuff? Well, it depends on who you are. This particular demo will be available to developers running early Chrome Canary builds in just a few weeks, and Google held an immersive web session at I/O to get those folks ready to start crafting in-browser AR experiences. Sadly, everyone else is going to have to wait — the APIs Google is using to make these experiences possible aren’t final yet, so there’s really no way of knowing when our browsers will get these major updates. Google offered some hope, though: A lot of the code around in-browser VR applies here as well, so developers won’t have to start from scratch. We’re obviously still in for a long wait, but considering 100 million phones and tablets out there technically support augmented reality, it’s important that Google and its partners get these experiences right.

Click here to catch up on the latest news from Google I/O 2018!

Tech

via Engadget http://www.engadget.com

May 9, 2018 at 03:39PM

Google Pixel Buds let you customize which apps send spoken notifications

Google Pixel Buds let you customize which apps send spoken notifications

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Los Pixel Buds

A beta preview back in March hinted at a few features coming to Google’s Pixel Buds, like expanded double-tap functionality and in-ear detection. But there’s another addition coming for the wireless headphones: New settings to switch spoken notifications on or off for each app.

Previously, Android users only had a basic toggle to activate or deactivate spoken notifications sent to Assistant headphones for all apps at once. Now they can go app by app, switching on the vocalized alerts to their comfort. Messaging services are the only ones that deliver notifications by default, so you’ll have to click the others ‘on’ manually. Finally, this doesn’t seem like an upgrade to the Pixel Buds themselves but through the Google app, theorized 9to5Google, since they appeared after downloading Android 8.2.

Tech

via Engadget http://www.engadget.com

May 9, 2018 at 05:45PM

ZTE Ceases Operations After US Government Ban

ZTE Ceases Operations After US Government Ban

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zte shut down

ZTE has mostly shut down its main business operations, according to Reuters, after the US government banned US companies from supplying it with components. ZTE did say that it is trying to get a modification or reversal to the ban, though.

Because ZTE makes a lot of the products using components from Qualcomm and Intel, a ban on US companies supplying them is a huge hit. We knew it would be when the US government announced the ban, but man, this is all happening very quickly.

ZTE can always try to find other suppliers for its components. The problem is, there aren’t many alternatives. Mediatek is a mobile chipset maker that could step in to provide some relief.

Remember, as you possibly feel bad for ZTE in all of this – the reason they got this US supply ban was because they lied about paying bonuses to workers. They were initially in trouble with the US for supplying electronics to Iran, but after being slapped with heavy fines for that, they failed to follow through on additional rules set by the US government. ZTE was supposed to fire certain employees involved in that Iran deal and also vacate bonuses to a bunch of other employees. When the US government found out that they lied about the bonuses and paid them anyway, that’s when this latest, crippling ban happened.

We’ll keep you updated on ZTE, but things sure do look bad at the moment.

// Reuters

ZTE Ceases Operations After US Government Ban is a post from: Droid Life

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via Droid Life: A Droid Community Blog https://ift.tt/2dLq79c

May 9, 2018 at 01:09PM