The Price of This Drug Went Up 100,000 Percent Since 2001 for No Good Reason

The Price of This Drug Went Up 100,000 Percent Since 2001 for No Good Reason

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Photo: File photo of an office for Mallinckrodt Pharmaceuticals, maker of Acthar (AP)

Did you catch 60 Minutes last night? If you did, you may have learned about a drug called Acthar that went from $40 in 2001 to over $40,000 today. It’s a perfect illustration of just how poorly regulated the US pharmaceutical industry continues to be and how there’s absolutely no good reason for the extreme prices Americans pay for medicine.

Acthar has been on the market since 1952 and is primarily used to treat infantile spasms, a rare condition. Why does Acthar cost $40,000 today, an increase of 100,000 percent from the cost in 2001? Pure greed.

You can buy an identical drug to Acthar called Synacthen for just $33 in Canada. Synacthen is also available in Europe, where the drug is also reasonably priced. But the company that currently makes Acthar in the United States, Mallinckrodt Pharmaceuticals, bought the rights to Synacthen in America and doesn’t sell it in the US.

If you didn’t catch the episode of 60 Minutes, you need to watch it right now. Or, don’t, if you’re trying to keep your blood pressure down.

What does the company have to say for itself? Mallinckrodt insists that the price hike occurred before it bought Questcor pharmaceuticals in 2014, which used to produce Acthar. Mallinckrodt owns Questcor now, but told 60 Minutes in a series of emails that it’s not doing anything. The company didn’t send a representative to appear on camera.

The story of Acthar should be familiar to anyone who followed the EpiPen saga of 2016. The price of the EpiPen, a common injectable drug product for allergies, went from $57 in 2007 to roughly $600 in 2016. Mylan, the maker of EpiPen, did absolutely nothing to improve the product while it engaged in this price gouging. Thankfully, the US Justice Department appears to be investigating Mylan and according to some reports might finally bring charges this year against the company for a host of allegations, including price fixing. The investigation into Mylan reportedly started in 2014. But we’ll see if anyone goes to jail.

As for Mallinckrodt, that company will continue to charge $40,000 for a drug that’s been out of patent for decades. And they’ve even expanded the marketing for the drug to treat things like rheumatoid arthritis. As you can see from the episode, there’s no real evidence that Acthar is effective in treating arthritis.

With any luck, the US Department of Justice will take a look at Mallinckrodt soon. But, until then, people who need to buy Acthar for their babies better have insurance. Because even if that $40,000 price tag is pushed down, there are still countless other ways that American continue to get screwed on drug prices.

Much of the rest of the world doesn’t have to deal with this shit. Every other industrialized country guarantees health care for its citizens and is able to negotiate for better drug prices and impose strict regulations. The really sick part? Medicare isn’t legally allowed to negotiate drug prices, leading to extreme price gouging by drug companies across the board. Roughly 92 percent of Americans believe that Medicare should be able to negotiate drug prices, but the drug lobby is a behemoth that is easily allowed to trample democracy.

The Trump regime has promised to crack down on drug prices for Americans, but so far all we’ve gotten are empty promises. If President Trump really wanted to distract from his current troubles, perhaps he could take up one of the most popular causes around: Actually lowering drug prices by finally telling the pharmaceutical industry that enough is enough.

[60 Minutes]

Tech

via Gizmodo http://gizmodo.com

May 7, 2018 at 07:00AM

Handheld skin printer could help heal burn victims

Handheld skin printer could help heal burn victims

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University of Toronto/Liz Do

A handheld device that deposits skin directly onto patients’ wounds could revolutionize the way that doctors treat burns and other wounds. The printer, developed by University of Toronto researchers, is used like a white-out tape dispenser, rolling out protein-based biomaterials like collagen directly on the affected area. It can be used instead of a regular skin graft, but doesn’t require healthy skin to be removed from a donor.

“Most current 3D bioprinters are bulky, work at low speeds, are expensive and are incompatible with clinical application,” said U of T Associate Professor Axel Guenther. Their printer, on the other hand, weighs two pounds, making it feasible to use during surgery. It’s also the first device that can form tissue, depositing and setting it in-situ, within two minutes or less, the team said.

Patients with deep wounds often have damage to all of their skin layers, including the hypodermis, dermis and epidermis. Doctors would normally treat that with a technique called split-thickness skin grafting, but if the wound is too large, it’s difficult to find a sufficient quantity of donor skin. That leaves portions uncovered, leading to healing problems.

The U of T bioprinter could fill that gap, letting doctors quickly apply collagen, the most common dermis protein, and a protein associated with healing, fibrin, to untreated parts of the wound. “Our skin printer promises to tailor tissues to specific patients and wound characteristics,” said PhD student Navid Hakimi.

We’ve seen other 3D skin printing solutions before, but they’ve yet to be applied to human patients. The U of T team hasn’t used the tech on people either, but has tested it on pigs. Next up, the team plans to add new capabilities like enlarging the printer width to cover wider wounds. They’ll also perform more in vivo studies at Toronto’s Sunnybrook hospital, with the goal of eventually testing it on humans.

Tech

via Engadget http://www.engadget.com

May 7, 2018 at 07:21AM

Microsoft’s Android launcher can run apps from your Windows Timeline

Microsoft’s Android launcher can run apps from your Windows Timeline

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Jon Fingas/Engadget

Windows 10’s Timeline feature is now decidedly more useful away from your PC, provided you use the right software. To start, Microsoft Launcher on Android now supports Timeline — you can pick up where you left off with cross-platform titles. iPhone users, meanwhile, can access Timeline through Microsoft’s Edge browser.

Microsoft Launcher is also receiving proper enterprise support with updates for discovering line of business apps and IT configuration advisement. If you live in a Microsoft-heavy workplace, you may not have to do much to get your device ready for use.

There isn’t much more information about these features today, but Microsoft is expected to share additional details on May 8th.

Click here to catch up on the latest news from Microsoft Build 2018!

Tech

via Engadget http://www.engadget.com

May 7, 2018 at 10:33AM

Uber crash reportedly caused by software that ignored objects in road

Uber crash reportedly caused by software that ignored objects in road

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Así es el coche autónomo de Uber – REUTERS/Natalie Behring

Uber has reportedly discovered that the fatal crash involving one of its prototype self-driving cars was probably caused by software faultily set up to ignore objects in the road, sources told The Information. The autonomous programming detects items around the vehicle and operators fine-tune its sensitivity to make sure it only reacts to true threats (solid objects instead of bags, for example). Unfortunately, the car’s software was supposedly set too far in the other direction, and didn’t stop in time to avoid hitting bicyclist Elaine Herzberg.

There was a human driver behind the wheel, but they reportedly took their eyes off the road in the seconds leading up to the crash. Uber settled with the family of the victim, but the resulting panic caused the Arizona governor to halt all testing, and other companies voluntarily delayed their own testing until the dust settled. Uber is conducting an investigation into the system alongside the National Transportation Safety Board (NTSB), but the ridesharing company is expected to reach an initial conclusion far ahead of the NTSB’s much more detailed report.

Tech

via Engadget http://www.engadget.com

May 7, 2018 at 12:39PM

Sophisticated Android malware tracks all your phone activities

Sophisticated Android malware tracks all your phone activities

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NurPhoto via Getty Images

An advanced type of malware can spy on nearly every Android smartphone function and steal passwords, photos, video, screenshots and data from WhatsApp, Telegram and other apps. “ZooPark” targets subjects in the Middle East and was likely developed by a state actor, according to Kaspersky Lab, which first spotted and identified it.

ZooPark has evolved over four generations, having started as simple malware that could “only” steal device account details and address book contacts. The last generation, however, can monitor and exfiltrate keylogs, clipboard data, browser data including searching history, photos and video from the memory card, call records and audio, and data from secure apps like Telegram. It can also capture photos, video, audio and screenshots on its own, without the subject knowing. To get the data out, it can silently make calls, send texts and execute shell commands.

Kaspersky — a company with its own spotty security history that has been banned by the US government — said that it has seen less than 100 targets in the wild. “This and other clues indicates that the targets are specifically selected,” Kasperky Lab’s Alexey Firsh told ZDNet. It also implies that the campaign is backed by a nation state, though the security firm didn’t say which.

At the same time, Kaspersky suggested that the malware might not have been built in-house. “The latest version may have been bought from vendors of surveillance tools,” it wrote. “That wouldn’t be surprising, as the market for those espionage tools is growing, becoming popular among governments, with several known cases in the Middle East.”

As is now known, a lot of those tools came from the US government itself. A group called Shadow Brokers famously stole exploits from the NSA — some of the zero day, unpatched variety — and eventually released them to the public. In other words, a hacking group was able to obtain malware from what should be the most secure agency in the world. That’s one of the reasons that security experts and companies like Apple don’t trust the US government with device backdoors.

Tech

via Engadget http://www.engadget.com

May 7, 2018 at 02:15AM

Drug made famous by Shkreli’s 5,000% price hike is still $750 a pill

Drug made famous by Shkreli’s 5,000% price hike is still $750 a pill

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Enlarge /

Martin Shkreli, former CEO of Turing, smirked his way through a Congressional hearing.

Disgraced ex-pharmaceutical executive and hedge fund manager Martin Shkreli is now behind bars, facing a seven-year prison sentence for securities fraud. Yet the drug-price hike that initially thrust him into the public spotlight—and infamy—hasn’t budged, according to a sobering report by Kaiser Health News.

Tech

via Ars Technica https://arstechnica.com

May 4, 2018 at 10:02AM