FA=high-fat, ab libitum (eat-at-will) diet, FT=high-fat, time-restricted diet, NA=normal ab libitum (eat-at-will)Â diet, NT=normal diet, time-restricted
Diets tell you what you eat, but a new study suggests when you eat matters too. Of two groups of mice who were fed the same high-fat diet, the mice who could eat around the clock were much heavier than those who had food restricted to eight hours per day, in a new study published in Cell Metabolism.Â
Researchers in the study gave the mice a special high-fat chow, 61% of whose calories come from fat (compared to just 13% in normal feed). The mice who chowed down all day and night became, unsurprisingly, obese, but the ones who ate the same amount of hi-fat food in only eight hours per day did not. Their body weight was comparable to mice fed an equivalent amount of calories on normal feed.
This being a study in Cell Metabolism, the researchers didn’t stop with just weighing the mice; they did a lot of molecular experiments to work out the link between timing and weight gain. Mice on high-fat, eat-whenever diets had the insulin problems associated with obesity-induced diabetes and lower expression of genes linked to breaking down fats in the …
from Discover Magazine