From Discover Magazine: Malaria parasites evolve in vaccinated mice to cause more severe disease | Not Exactly Rocket Science

Curing disease is really a matter of outfoxing evolution. When we assault bacteria or viruses or cancer cells with drugs, they evolve ways of resisting those drugs. We attack, they counter-attack. Take malaria: the Plasmodium parasites that cause the disease have repeatedly evolved to resist our best anti-malarial drugs. The mosquitoes that carry the parasites have evolved to resist the insecticides we poison them with. And now, Victoria Barclay from Pennsylvania State University has found that some malaria vaccines could drive Plasmodium to become even deadlier than it is now.

Several malaria vaccines are in development, but none have been licensed yet. Barclay vaccinated mice with a protein that’s found in several of these vaccines, and then exposed them to Plasmodium. After a few generations, the parasite became more ‘virulent’ – that is, it caused more severe disease. And it did so via an evolutionary escape route that is rarely considered.

Vaccine creators aren’t naive to the possibility of resistance. They’re trying to train the immune system to recognise and destroy Plasmodium by presenting them with proteins on the parasite’s surface, and they know that the parasites could …

from Discover Magazine

From Engadget: Verizon to stop blocking tethering apps, settles with FCC for $1.25 million

Verizon to stop blocking tethering apps, settles with FCC for $1.25

In May of last year, our free ride came to an end. US carriers started blocking third party tethering apps in the Android Market. Not long after, the built in feature was turned off on most phones. Our fortune may be reversing, however. The FCC has ruled that Verizon violated the rules governing the C Block of LTE spectrum by preventing consumers from using any application of their choice. The end result: Big Red will have to open up its airwaves and allow customers to circumvent its $20 a month tethering plan using apps from the Play store — so long as you’re on a “usage-based pricing plan.” Though it’s not explicitly stated, we assume that means those of you lucky enough to be grandfathered in to the unlimited data plans are left out. In addition to unblocking apps such as PdaNet and Barnacle, Verizon must pay a $1.25 million settlement to put an end to the investigation. For a few more details of the plan put in place to ensure compliance with the ruling, check out the PR after the break.

 

from Engadget

From Popular Science – New Technology, Science News, The Future Now: Video: Four-Ton Japanese Mega Bot Fires BBs At Smiling Humans

Kuratas via Plastic Pals

This boxy guy is called Kuratas, otherwise known as Vaudeville, and he stands 12 feet 5 inches tall. He weighs about 4.5 tons and is diesel-powered. Do not smile at him. He will shoot that grin right off your face.

Kuratas is a real-life mech from (where else?) Japan, and it’s an art project designed by Suidobashi Heavy Industry. Iron worker/artist Kogoro Kurata, at right in the photo above, built his namesake robot and debuted it at something called Wonder Fest 2012, which took place over the weekend.

It has a ride-in cockpit, a master-slave joystick and a touchscreen interface, and its arms can be controlled via Kinect, so it could be trained as a champion boxer. Its twin BB Gatling guns can fire up to 6,000 BBs per minute, according to Plastic Pals. And it fires when a small camera inside the robot detects when you smile. This is just for fun, however – Kurata says he would never want his creation to harm anyone. But it could be used for robot competitions, he said.

You could pretend-order one of your own, via a slick website Kurata and his colleagues at Suidobashi designed. The mecha come in various color schemes and customizable weapons. But the base model starts at $1,353,500, so better start saving.

[Plastic Pals]

 

from Popular Science – New Technology, Science News, The Future Now

From Morning Edition: N.J. Mom Puts Kids To Bed With Math

The U.S. ranks 25th out of 34 countries when it comes to kids’ math proficiency. One New Jersey parent wants to change that by overhauling the culture of math. An astrophysics graduate and mother of three kids, she started a ritual when each child was 2 years old: a little bedtime mathematical problem-solving that soon became a beloved routine. Parent friends began to bug her to send them kid-friendly math problems, too. Now Bedtime Math is gaining fans among children and math-shy parents around the country.

 

from Morning Edition